When combined with diet and exercise, studies have shown that half of the participants lost 10% of their body weight and four-fifths lost 5% (which equates to 12 pounds in a 227-pound person). Topiramate is associated with a high risk of birth defects such as cleft lip and palate. Phentermine was one of the ingredients in fen-phen and is associated with an elevation in heart rate.
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